1. Please keep the attitude, crude humor, and babes, but make them GOOD this time. Without these it's not a DN game.
2. More open and explorable levels, a la Duke 3D. Keep away from CoD-style set pieces and linearity.
Lots of awesome weapons (and let me carry at least 4 like in the PC version)
Lots of stuff to blow up
Lots of cool toys (jetpack, holoduke, etc.)
Make it fun! I want to feel like a badass!